Peer Review for EPA’s Biologically Based Dose-Response (BBDR) Model for Perchlorate
Citation:
Peer Review for EPA’s Biologically Based Dose-Response (BBDR) Model for Perchlorate.
Impact/Purpose:
EPA is undertaking a peer review to provide a focused, objective independent peer evaluation of the draft model and its model results report. Peer review is an important component of the scientific process. The criticism, suggestions, and new ideas provided by the peer reviewers stimulate creative thought, strengthen the interpretation of the reviewed material, and confer credibility on the product. The peer review objective is to provide advice to EPA on steps that will yield a highly credible scientific product that is supported by the scientific community and a defensible perchlorate MCLG.
Description:
EPA is developing a regulation for perchlorate in drinking water. As part the regulatory process EPA must develop a Maximum Contaminant Level Goal (MCLG). FDA and EPA scientists developed a biologically based dose-response (BBDR) model to assist in deriving the MCLG. This model is designed to determine under what conditions of iodine nutrition and exposure to perchlorate across sensitive lifestages would result in low serum free and total thyroxine (hypothyroxinemia). EPA is undertaking a peer review to provide a focused, objective independent peer evaluation of the draft model and its model results report.
URLs/Downloads:
External Peer Review for EPA’s Draft Biologically Based Dose-Response (BBDR) Model and Draft BBDR Model Report for Perchlorate in Drinking Water (PDF, NA pp, 1872 KB, about PDF)Federal Register Notice (10/25/2016) extension of comment period
Federal Register Notice (09/30/2016) comment external reviewers
Biologically Based Dose Response Models for the Effect of Perchlorate on Thyroid Hormones in the Infant, Breast Feeding Mother, Pregnant Mother, and Fetus (PDF, NA pp, 3686 KB, about PDF)
Federal Register Notice (03/01/2016) 1st nomination of reviewers
Federal Register Notice (09/30/2016) comment on BBDR Model
Federal Register Notice (06/03/2016) 2nd nomination of reviewers
Federal Register Notice (12/05/2016) Final Reviewers and Charge