You are here:
High-Throughput Toxicokinetics (HTTK) R package (CompTox CoP presentation)
Citation:
Wambaugh, J. High-Throughput Toxicokinetics (HTTK) R package (CompTox CoP presentation). Presented at CompTox CoP, RTP, NC, December 10, 2015. https://doi.org/10.23645/epacomptox.5067670
Impact/Purpose:
This is a presentation to the EPA’s Computational Toxicology Communities of Practice. The presentation is intended to communicate the existence and use of a new tool for toxicokinetics that has been developed by the Rapid Exposure and Dosimetry project.
Description:
Toxicokinetics (TK) provides a bridge between HTS and HTE by predicting tissue concentrations due to exposure, but traditional TK methods are resource intensive. Relatively high throughput TK (HTTK) methods have been used by the pharmaceutical industry to determine range of efficacious doses and to prospectively evaluate success of planned clinical trials (Jamei, et al., 2009; Wang, 2010). A key application of HTTK has been “reverse dosimetry” (also called Reverse TK or RTK). RTK can approximately convert in vitro HTS results to daily doses needed to produce similar levels in a human for comparison to exposure data (Wetmore, et al., 2012). We have developed an R package for performing RTK that is freely available and open source.
URLs/Downloads:
DOI: High-Throughput Toxicokinetics (HTTK) R package (CompTox CoP presentation)
WAMBAUGH_EXPOCAST-HTTK-121015.PDF (PDF, NA pp, 2264.189 KB, about PDF)