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The ToxCast Chemical Prioritization Program at the US EPA (UCLA Molecular Toxicology Program)
Citation:
Houck, K. The ToxCast Chemical Prioritization Program at the US EPA (UCLA Molecular Toxicology Program). Presented at UCLA Molecular Toxicology Program, Los Angeles, CA, November 12, 2015. https://doi.org/10.23645/epacomptox.5071285
Impact/Purpose:
Invited seminar and visit to UCLA Molecular Toxicology program.
Description:
To meet the needs of chemical regulators reviewing large numbers of data-poor chemicals for safety, the EPA's National Center for Computational Toxicology is developing a means of efficiently testing thousands of compounds for potential toxicity. High-throughput bioactivity profiling is used to generate data to predict, through a variety of modeling approaches, the potential for toxicity. Combined with high-throughput exposure models also being developed, these results can be used to prioritize chemicals for more detailed toxicological analysis. Examples will be provided for prioritizing compounds for the endocrine disruptor screening program.
URLs/Downloads:
DOI: The ToxCast Chemical Prioritization Program at the US EPA (UCLA Molecular Toxicology Program)
HOUCK_UCLA_2015_FINAL.PDF (PDF, NA pp, 7747.496 KB, about PDF)