You are here:
EXTRACTION AND ANALYSIS OF LEWISITE 1, BY ITS DEGRADATION PRODUCTS, USING LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC-MS/MS)
Citation:
U.S. EPA. EXTRACTION AND ANALYSIS OF LEWISITE 1, BY ITS DEGRADATION PRODUCTS, USING LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC-MS/MS). U.S. Environmental Protection Agency, Washington, DC, 2015.
Impact/Purpose:
This method has been developed to address the analysis of Lewisite 1 degradation products in environmental matrices (water, soil, and wipes) by LC-MS/MS. Because Lewisite 1 hydrolyzes quickly in the environment to CVAA and then oxidizes more slowly to CVAOA, the standard operating procedure that has been developed extracts Lewisite 1 degradation products from the matrices of interest and converts them to CVAOA prior to analysis. The presence of CVAOA and/or CVAA is indicative of Lewisite 1 contamination, as there are no known natural sources for these compounds. Phenyl arsonous acid (PAA), which can be oxidized to phenyl arsonic acid (PAOA), is used as a surrogate to show that both extraction and oxidation processes have been successfully implemented.
Description:
Methods Report