EPA Science Inventory

IRIS Toxicological Review of Inorganic Arsenic (Preliminary Assessment Materials)

Notice:

EPA hosted an IRIS public science meeting on June 25-27, 2014, to provide an opportunity for the public to give input and participate in an open discussion regarding preliminary materials that were prepared for the IRIS chemicals, hexavalent chromium (Cr(VI)) and inorganic arsenic (iAs), prior to the development of the draft assessment.

Citation:

U.S. EPA. IRIS Toxicological Review of Inorganic Arsenic (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/630/R-14/101, 2014.

Description:

In April 2014, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for inorganic arsenic (iAs) to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in comments on the following:

  • Draft literature search strategies
    • The approach for identifying studies
    • The screening process for selecting pertinent studies
    • The resulting list of pertinent studies
  • Preliminary evidence tables
    • The process for selecting studies to include in evidence tables
    • The quality of the studies in the evidence tables
The literature search strategy, which describes the processes for identifying scientific literature, contains the studies that EPA considered and selected to include in the evidence tables. The preliminary evidence tables and exposure-response arrays present the key study data in a standardized format. The evidence tables summarize the available critical scientific literature. The exposure-response figures provide a graphical representation of the responses at different levels of exposure for each study in the evidence table.

Purpose/Objective:

This draft IRIS health assessment addresses only cancer human health effects that may result from chronic exposure to this chemical.

URLs/Downloads:

Scoping information, preliminary literature search, associated strategy and evidence tables for iAs   (PDF,731 pp, 8009 KB,  about PDF)

Primary literature search references sorted by author (iAs)

IRIS June 2014 Meeting & Presentations

Literature selection process for the iAs primary literature

Record Details:

Record Type: DOCUMENT (IRIS ASSESSMENT)
Start Date: 04/17/2014
Record Last Revised: 12/05/2016
Record Created: 10/08/2015
Record Released: 04/17/2014
OMB Category: Highly Influential
Record ID: 309710

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT

IMMEDIATE OFFICE