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Assessing the exposure and toxicological implications of environmental transformations of graphene oxide using in vitro methods
Citation:
Henderson, Matt, I. Chowdhury, W. Hou, X. Chang, S. Martin, R. Zepp, AND D. Bouchard. Assessing the exposure and toxicological implications of environmental transformations of graphene oxide using in vitro methods. 250th American Chemical Society National Meeting & Exposition, Boston, MA, August 16 - 20, 2015.
Impact/Purpose:
Presentation at American Chemical Society National Meeting, Boston, MA; August 16-20, 2015
Description:
Graphene oxide (GO) and graphene-based nanoparticles are increasingly being used in biomedical, environmental, and industrial applications due to their distinct chemical and physical properties. Their widespread use and application can potentially result in mass release of GO to the aquatic environment. Understanding the environmental transformation and fate of GO is necessary to accurately assess its ecological impact. Studies have demonstrated that GO is cytotoxic in numerous species but few have focused on investigating GO toxicity under environmental conditions. The objective of this study was to investigate the exposure potential of GO and its transformation products in ecologically relevant species. To this end, GO and GO products were characterized using advanced analytical techniques prior to exposure studies. In vitro biomarker-based approaches were then utilized to identify pathways involved in GO toxicity. These studies, with identification of GO transformation products, will aid in assessing the ecotoxicity associated with this class of materials.
