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DOMINANT LETHAL EFFECTS OF SUBCHRONIC ACRYLAMIDE ADMINISTRATION IN THE MALE LONG-EVANS RAT
Citation:
Smith, M., H. Zenick, R. Preston, E. George, AND R. Long. DOMINANT LETHAL EFFECTS OF SUBCHRONIC ACRYLAMIDE ADMINISTRATION IN THE MALE LONG-EVANS RAT. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-86/059 (NTIS PB86204633).
Description:
Acrylamide, a widely used vinyl monomer, is well known as a neurotoxin but inactive as a mutagen in bacterial test systems. The experiments reported demonstrate that after subchronic oral dosing in the male rat, acrylamide induced significant elevations in both pre and post implantation loss following dominant lethal testing. These effects were seen at doses which failed to produce clinical or pathological evidence of neurotoxicity.
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DOMINANT LETHAL EFFECTS OF SUBCHRONIC ACRYLAMIDE ADMINISTRATION IN THE MALE LONG-EVANS RATRecord Details:
Record Type:DOCUMENT( REPORT )
Product Published Date:05/24/2002
Record Last Revised:04/16/2004
Record ID:
30733