Science Inventory

Conceptual Model for Assessing Criteria Air Pollutants in a Multipollutant Context: A Modified Adverse Outcome Pathway Approach

Citation:

Buckley, B. AND A. Farraj. Conceptual Model for Assessing Criteria Air Pollutants in a Multipollutant Context: A Modified Adverse Outcome Pathway Approach. TOXICOLOGY. Elsevier Science Ltd, New York, NY, 335:85-94, (2015).

Impact/Purpose:

The purpose of this manuscript is to apply the adverse outcome pathway paradigm to criteria air pollutants in a multipollutant context.

Description:

Background: Air pollution consists of a complex mixture of particulate and gaseous components. Individual criteria and other hazardous air pollutants have been linked to adverse respiratory and cardiovascular health outcomes. However, assessing risk of air pollutant mixtures is difficult since components are present in different combinations and concentrations in ambient air. Recent mechanistic studies have limited utility because of the inability to link measured changes to adverse outcomes that are relevant to risk assessment. New approaches are needed to address this challenge. Objective: This purpose of this manuscript is to describe a conceptual model, based on the Adverse Outcome Pathway approach, which connects initiating events at the cellular and molecular level to population-wide impacts. This may facilitate hazard assessment of air pollution mixtures. Results: In the case reports presented here, airway hyperresponsiveness and endothelial dysfunction are measurable endpoints that serve to integrate the effects of individual criteria air pollutants found in inhaled mixtures. This approach incorporates information from experimental and observational studies into a sequential series of higher order effects. Discussion and Conclusions: The proposed model has the potential to facilitate multipollutant risk assessment by providing a framework that can be used to converge the effects of air pollutants in light of common underlying mechanisms. This approach may provide a ready-to-use tool to facilitate evaluation of health effects resulting from exposure to air pollution mixtures.

URLs/Downloads:

http://www.sciencedirect.com/science/article/pii/S0300483X153001   Exit

BUCKLEY.PDF   (PDF,NA pp, 4880 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Product Published Date: 07/18/2015
Record Last Revised: 06/03/2016
OMB Category: Other
Record ID: 306351

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT

RESEARCH TRIANGLE PARK NC

ENVIRONMENTAL MEDIA ASSESSMENT GROUP