EPA Science Inventory

Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology (Final Report)

Citation:

U.S. EPA. Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology (Final Report). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-14/004, 2014.

Description:

EPA announced the release of the final report, Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology. This report describes new approaches that are faster, less resource intensive, and more robust that can help address the challenges of assessing potential health hazards for large number of chemicals introduced into the environment and to evaluate their safety from the perspective of human health. This report describes how new molecular, computational and systems biology data and approaches (together called "NexGen") could better inform risk assessment. The report summarizes the state of the science and provides prototypes, which are case studies that use available NexGen information.

Purpose/Objective:

The large number of chemicals introduced into the environment has overwhelmed our ability to evaluate their safety from the perspective of human health. This report describes the results of a multiyear, multi-organization effort to evaluate new approaches to environmental risk assessment, referred to as NexGen risk assessments, and provides a scientific basis for modernizing the risk assessment process

URLs/Downloads:

Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology (EPA/600/R-14/004)   (PDF,196 pp, 5450 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (PUBLISHED REPORT/REPORT)
Projected Completion Date: 09/12/2014
Record Last Revised: 03/20/2017
Record Created: 09/16/2014
Record Released: 09/21/2014
OMB Category: Other
Record ID: 286690

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT