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TERATOLOGY v2.0 – building a path forward
Citation:
Knudsen, T. TERATOLOGY v2.0 – building a path forward. Presented at Teratology Society 2014 Annual Meeting, Bellevue, WA, June 28 - July 02, 2014. https://doi.org/10.23645/epacomptox.5080300
Impact/Purpose:
Joseph Warkany Lecture, by invitation
Description:
Unraveling the complex relationships between environmental factors and early life susceptibility in assessing the risk for adverse pregnancy outcomes requires advanced knowledge of biological systems. Large datasets and deep data-mining tools are emerging resources for predictive modeling that can be broadly applied to the analysis of developmental pathways, processes and toxicities. For the teratologist, does this ‘big data’ stream represent a new solution for traditional problems, or new problems for traditional solutions? Reducing a complex embryological system into simpler components on one hand may facilitate analysis, but on the other hand disrupts precisely the combination of qualities and features that makes the system complex in the first place. Multi-cellular interactions ultimately determine the resolution of molecular impairment(s) into critical effects that ultimately determine a developmental defect or disability. This lecture will focus on challenges and opportunities associated with utilizing complex data for predictive and mechanistic understanding of teratogenesis, strategies to interact big-data with principles of teratology for hypothesis generation and adverse outcome pathway elucidation, and spatio-temporal prediction utilizing the major organizing principles of dosimetry, criticality, and susceptibility. (This abstract does not reflect US EPA policy).
URLs/Downloads:
DOI: TERATOLOGY v2.0 – building a path forward
WARKANY_LECTURE_ABSTRACT_KNUDSEN_TERATOLOGYSOCIETY2014.PDF (PDF, NA pp, 262.105 KB, about PDF)
WARKANY_LECTURE_PRESENTATION_KNUDSEN_TERATOLOGYSOCIETY2014.PDF (PDF, NA pp, 5168.222 KB, about PDF)