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Meeting Report: FutureTox II: Contemporary Concepts in Toxicology “Pathways to Prediction: In Vitro and In Silico Models for Predictive Toxicology”
Citation:
Elmore, S., A. Ryan, C. Wood, T. Crabbs, AND R. Sills. Meeting Report: FutureTox II: Contemporary Concepts in Toxicology “Pathways to Prediction: In Vitro and In Silico Models for Predictive Toxicology”. TOXICOLOGIC PATHOLOGY. Society of Toxicology, RESTON, VA, 42(5):940-942, (2014).
Impact/Purpose:
Predictive toxicology approaches have an increasingly prominent role in chemical prioritization and safety assessment at EPA. The pathology community has important expertise in developing and validating these models but to date has not been strongly engaged in this effort. This meeting summary was intended to generate interest and highlight opportunities for pathologists in this field. The work broadly supports goals of Theme 2 (Systems Models) within the ORD Chemical Safety for Sustainability (CSS) research program (Task 2.2.1).
Description:
The Society of Toxicology (SOT) held avery successful FutureTox II Contemporary Concepts in Toxicology (CCT) Conference in Chapel Hill, North Carolina, on January 16th and 17th, 2014. There were over 291 attendees representing industry, government and academia; the sessions were also telecast to 9 locations, including Health Canada, US FDA/National Center for Toxicologic Research, the US EPA and the California EPA Office of Environmental Health Hazard Assessment The conference also included more than 50 posters as well as several vendor exhibits. The theme of the meeting was ‘Pathways to Prediction: In Vitro and In Silico Models for Predictive Toxicology.” This conference was the product of the Scientific Liaison Coalition (SLC), which is a partnership of 16 societies, including the Society of Toxicologic Pathology, with the aim to increase the awareness and impact of toxicology on human health and disease prevention. The focus of this FutureTox II meeting was integration of current and developing in vitro methodologies and computational modeling approaches with advances in systems biology to facilitate human risk assessment. The overarching theme in each session was to articulate the current strengths and limitations of these newer approaches and their utility in prioritizing chemicals for safety testing.