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Current Status of Chemical Public Health Risks and Testing Guidelines for Chemical Cardiovascular Safety Assessments
Citation:
Dreher, K. Current Status of Chemical Public Health Risks and Testing Guidelines for Chemical Cardiovascular Safety Assessments. Presented at "Translational Alternative Models and Biomarkers Predictive of Drug or Chemical Cardiovascular Risk Workshop", Research Triangle Park, NC, October 10 - 11, 2013.
Impact/Purpose:
Will be presented at the Workshop titled "Translational Alternative Models and Biomarkers Predictive of Drug or Chemical Cardiovascular Risk", NIH, NIEHS, Research Triangle Park, NC Meeting Dates: October 10 – 11, 2013
Description:
The cardiovascular system, at all its various developmental and life stages, represents a critical target organ system that can be adversely affected by a variety of chemicals and routes of exposure. A World Health Organization report estimated the impact of environmental chemical exposures on health to be 16% (range: 7—23%) of the total global burden of cardiovascular disease, corresponding to ~2.5 million deaths per year. Currently, the overall impact of environmental chemical exposures on all causes of cardiovascular disease and the number one cause of morbidity and mortality in the United States is unknown. Evidence from epidemiology, clinical, and toxicological studies will be presented documenting adverse cardiovascular effects associated with environmental exposure to chemicals. The presentation will cover US EPA’s ability to regulate and test chemicals as well as current challenges faced by the Agency to assess chemical cardiovascular risk and public health safety. (This abstract does not necessarily reflect US EPA Policy)