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AOP Wiki: A new tool for developing and documenting adverse outcome pathways
Citation:
Ankley, G. AOP Wiki: A new tool for developing and documenting adverse outcome pathways. IN: SETAC Globe, SETAC Press, Pensacola, FL, 14(8), (2013).
Impact/Purpose:
not applicable
Description:
An initial version of an IT system to support OECD AOP activities recently was completed through collaborative efforts and contributions of the European Commission's Joint Research Centre (EU JRC), the Office of Research and Development (ORD) of the United States Environmental Protection Agency (USEPA), the US Army Corps of Engineers, and other parties. The AOP Wiki leads AOP developers through the steps necessary to capture the scientific information needed to document and evaluate an AOP following the recently published OECD guidance, and provides an ideal collaboration-space for international AOP-development project teams. While quite similar to Wikipedia, a system of user-friendly tables, drop-down-boxes and built-in functionality for automatic cross-referencing between related pages makes the system very easy to use. Thanks to the new IT system, AOP developers will be able to create an AOP wiki page and then link it to related information about MIEs, key events, AOs and chemical initiators. The entry of ontology-based information is simplified by controlled-vocabulary drop-down lists from which to select Methods, Actions, Biological Objects, Life stages, Species, etc. that are related to the AOP being developed. Information regarding key events and AOs shared among multiple AOPs is stored on a single page to eliminate redundant entries and make the collective knowledge about those entities available in all AOPs containing them. This format also facilitates the identification of potential intersections and cross-talk among AOPs.
URLs/Downloads:
AOP WIKI GLOBE ARTICLE.PDF (PDF, NA pp, 45.155 KB, about PDF)http://globe.setac.org/2013/august/outcome-pathways.html
