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Pathway-based monitoring of biological effects at Great Lakes sites (Presntation)
Citation:
Garcia-Reyero, N., Dan Villeneuve, L. Escalon, T. Habib, D. Ekman, E. Durhan, M. Kahl, K. Jensen, J. Cavallin, J. Berninger, Tim Collette, G. Ankley, AND E. Perkins. Pathway-based monitoring of biological effects at Great Lakes sites (Presntation). Presented at International Association of Great Lakes Research, West Lafayette, IN, June 02 - 06, 2013.
Impact/Purpose:
not applicable
Description:
The Great Lakes region suffers from degradation of water and environmental quality due to release of chemicals of emerging concern. Critical issues remain in delisting Areas of Concern (AOC) including determining sources of chemicals causing fish health impacts, relating health impacts to chemical exposure, and identifying causes of adverse health effects such as reproductive effects. Causal information would enable decision makers to identify more appropriate remedial actions thereby facilitating delisting of AOC. Fish placed in floating cages at different locations within AOC can be used to rapidly monitor the impacts of chemicals on fish health by analyzing chemicals in water, fish, and resulting impacts to fish health. Specific changes found in fish organs such as gonads and liver can be associated with specific effects. Here we show how a systems approach using transcriptomics, metabolomics, and other physiological endpoints has the potential to identify the health impacts caused by high-priority AOCs. We will also use changes at the molecular level to identify possible chemicals of concern based on associations with specific chemical exposures in the laboratory. We expect that this work will identify any potential health effects in fish leading to more accurate assessment of contaminant effects.