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One-Pot Catalyst-Free Synthesis of β- and γ-Hydroxy Sulfides using Diaryliodonium Salts and Microwave Irradiation
Citation:
Reddy, B. R., R. S. Varma, AND J. Leazer. One-Pot Catalyst-Free Synthesis of β- and γ-Hydroxy Sulfides using Diaryliodonium Salts and Microwave Irradiation. European Journal of Organic Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2012(35):6852-6855, (2012).
Impact/Purpose:
This write-up is the description of our paper published earlier in the peer-reviewed European Journal of Organic Chemistry (Eur. J. Org. Chem. 2012, 22, 6852-6855) and will be highlight in a Thieme synthesis journal, Synform.
Description:
A facile one-pot high-yield protocol is described for the preparation of β- and γ-hydroxy sulfides directly from diaryliodonium salts, potassium thiocyanate, and ethane-1,2-diol (ethylene glycol)/propane-1,3-diol (β-propylene glycol) without the need for any additional catalyst or base or solvent.
