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Development of a Comprehensive Morpholocially-Realistic Model of the Human Respiratory System for Dosimetric Use
Citation:
Burton, R., J. Rosati, G. McGregor, R. McCauley, W. Tang, AND R. Spencer. Development of a Comprehensive Morpholocially-Realistic Model of the Human Respiratory System for Dosimetric Use. Presented at Sigraph 2013, Anaheim, CA, July 21 - 25, 2013.
Impact/Purpose:
The project's goal is to model the inhalation, deposition, and clearance of aerosol-based contaminants, while making the model adaptable for age, race, sex, and health. We have made progress in parameterizing other variables that also define the subject's airways, such as changes created by respiratory disease, exposure to toxins, or stress. The model will also feature a dynamic morphology that mimics the changes in the airway structures during a typical breathing cycle. The model will therefore allow for any variation of airway geometries and disease states. The model could be critical to investigating sensitive populations, such as children, the elderly, and subjects affected by respiratory disease.The model's flexibility and adaptability could help researchers predict dose from exposure to hazardous contaminants, such as anthrax and ricin, and assist in estimating thresholds and the need for prophylactic measures. Finally, the model will also be useful to assist in targeting inhaled pharmaceuticals to the appropriate location in an individual's respiratory system.
Description:
Abstract Presentation
