NEW ENVIRONMENTAL PUBLIC HEALTH INDICATOR LINKING ORGANOCHLORINE COMPOUNDS AND TYPE 2 DIABETES
Impact/Purpose:
1) Determine if environmental (soil) levels of OC compounds and serum levels of OC compounds in people from a region of intense agriculture are greater than levels in soil and people from a less intensely farmed region.
2) Determine if a quantitative relationship exists between serum levels of OC compounds and the prevalence of endocrine disorders of glucose metabolism (T2D/prediabetes/increased insulin resistance).
Description:
The project will develop an environmental public health indicator (EPHI) by linking soil residues of organochlorine (OC) insecticides and metabolites/degradates, OC compound levels in people and a disease with which they are implicated, type 2 diabetes (T2D). The proposed EPHI would be serum levels of these OC compounds.
Record Details:
Record Type:PROJECT(
ABSTRACT
)
Start Date:04/01/2011
Completion Date:03/31/2014
Record ID:
249517
Keywords:
EXPOSURE, HEALTH EFFECTS, HUMAN HEALTH, ENVIRONMENTAL CHEMISTRY, MONITORING, ANALYTICAL, PERSISTENT ORGANIC POLLUTANTS,
Related Organizations:
Role
:OWNER
Organization Name
:MISSISSIPPI STATE UNIVERSITY - MAIN CAMPUS
Citation
:Mississippi State
State
:MS
Zip Code
:39762
Project Information:
Approach
:
Soil samples from 40 sites within a high agriculture area (Mississippi Delta) and 40 from a less intensively farmed area will be analyzed for OC analytes. Serum samples and demographic and clinical information will be obtained from male individuals, at least 45 years of age, from the Delta and non-Delta (150 in each region), and will be analyzed for OC compounds; deidentified samples and information will be supplied by the Veterans Administration from its patient pool.
Aim 1: The soil analytes will be statistically compared between the two regions and the serum analytes will be compared between the two regions.
Aim 2: Statistical models will be constructed to test for associations between the levels of the serum analytes and the occurrence of disorders of glucose metabolism. Explanatory variables will be included in the model: age, race, body mass index, and region of residence.
Cost
:$500,000.00
Research Component
:Air Quality and Air Toxics
Approach
:
Soil samples from 40 sites within a high agriculture area (Mississippi Delta) and 40 from a less intensively farmed area will be analyzed for OC analytes. Serum samples and demographic and clinical information will be obtained from male individuals, at least 45 years of age, from the Delta and non-Delta (150 in each region), and will be analyzed for OC compounds; deidentified samples and information will be supplied by the Veterans Administration from its patient pool.
Aim 1: The soil analytes will be statistically compared between the two regions and the serum analytes will be compared between the two regions.
Aim 2: Statistical models will be constructed to test for associations between the levels of the serum analytes and the occurrence of disorders of glucose metabolism. Explanatory variables will be included in the model: age, race, body mass index, and region of residence.
Cost
:$500,000.00
Research Component
:Human Health
Project IDs:
ID Code
:R834795
Project type
:EPA Grant