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Possible strategies for EDC testing in the future: exploring roles of pathway-based in silico, in vitro and in vivo methods
Ankley, G. Possible strategies for EDC testing in the future: exploring roles of pathway-based in silico, in vitro and in vivo methods. Presented at Special Science Symposium for SETAC, October 23 - 25, 2012.
Current methods for screening, testing and monitoring endocrine-disrupting chemicals (EDCs) rely relatively substantially upon moderate- to long-term assays that can, in some instances, require significant numbers of animals. Recent developments in the areas of in vitro testing (e.g., high through-put technologies), in vitro/in vivo genomics, and computational biology (including bioinformatics) could provide the basis for efficiently detecting chemicals with the potential to perturb specific biological pathways within the hypothalamic-pituitary-gonadal and -thyroidal axes. These approaches, while not yet capable of wholly replacing longer-term whole-organism tests, nonetheless could fill roles related to screening/prioritization of large numbers of test chemicals for endocrine activities, or rapid broad-scale environmental monitoring of EDCs. This presentation will explore some of the newer technologies being considered for EDC testing and monitoring, including their potential advantages and drawbacks.
Record Details:Record Type: DOCUMENT (PRESENTATION/SLIDE)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB
MID-CONTINENT ECOLOGY DIVISION