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IRIS Toxicological Review of Dibutyl Phthalate (Dbp) (Preliminary Assessment Materials)

Contact

phone: (202) 566-1676
fax: (202) 566-1749
email: hotline.iris@epa.gov
Notice:

EPA hosted an IRIS public science meeting on February 25-26, 2015, to provide an opportunity for the public to give input and participate in an open discussion regarding preliminary materials that were prepared for the IRIS chemicals, butyl benzyl phthalate (BBP), diisobutyl phthalate (DIBP), and dibutyl phthalate (DBP), prior to the development of the draft assessments.

Citation:

U.S. EPA. IRIS Toxicological Review of Dibutyl Phthalate (Dbp) (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-13/302, 2015.

Impact/Purpose:

The U.S. EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of dibutyl phthalate that will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.

Description:

In January 2015, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for DBP to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in comments on the following:

  • Draft literature search strategies
    • The approach for identifying studies
    • The screening process for selecting pertinent studies
    • The resulting list of pertinent studies
  • Preliminary evidence tables
    • The process for selecting studies to include in evidence tables
    • The quality of the studies in the evidence tables
The literature search strategy, which describes the processes for identifying scientific literature, contains the studies that EPA considered and selected to include in the evidence tables. The preliminary evidence tables and exposure-response arrays present the key study data in a standardized format. The evidence tables summarize the available critical scientific literature. The exposure-response figures provide a graphical representation of the responses at different levels of exposure for each study in the evidence table.

URLs/Downloads:

Scoping Information, Preliminary Literature Search, Associated Strategy and Evidence Tables for DBP  (PDF, 279 pp,  5100  KB,  about PDF)

Primary literature search references sorted by author (DBP) (dynamic literature link - generated by HERO, leaving the IRIS website)

Literature selection process for the DBP primary literature (dynamic literature link - generated by HERO, leaving the IRIS website)

Mechanistic table (DBP) (dynamic literature link - generated by HERO, leaving the IRIS website)

Targeted literature search for epidemiological references sorted by author (phthalate) (dynamic literature link - generated by HERO, leaving the IRIS website)

Literature selection process for the DBP targeted epidemiological literature (dynamic literature link - generated by HERO, leaving the IRIS website)

IRIS February 2015 Public Science Meeting & Presentations

Record Details:

Record Type:DOCUMENT( IRIS ASSESSMENT)
Product Published Date:01/14/2015
Record Last Revised:12/06/2016
OMB Category:Other
Record ID: 245171