Science Inventory

Stereo- and regio-selective one-pot synthesis of triazole-based unnatural amino acids and β- amino triazoles

Citation:

Baig, N. AND R. Varma. Stereo- and regio-selective one-pot synthesis of triazole-based unnatural amino acids and β- amino triazoles. CHEMICAL COMMUNICATIONS. RSC Publishing, Cambridge, Uk, 48(47):5853 - 5855, (2012).

Impact/Purpose:

Describe a green protocol that is applicable to a broad substrate scope and has significant potential for the synthesis of unnatural amino acids with triazole side chain.

Description:

Synthesis of triazole based unnatural amino acids and β-amino triazole has been described via stereo and regioselective one-pot multi-component reaction of sulfamidates, sodium azide, and alkynes under MW conditions. The developed method is applicable to a broad substrate scope and has significant potential for the synthesis of unnatural amino acids with triazole side chain.

URLs/Downloads:

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STEREO- AND REGIO-SELECTIVE ONE-POT SYNTHESIS OF TRIAZOLE-BASED UNNATURAL   Exit

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Product Published Date: 04/19/2012
Record Last Revised: 06/13/2012
OMB Category: Other
Record ID: 243950

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL RISK MANAGEMENT RESEARCH LABORATORY

SUSTAINABLE TECHNOLOGY DIVISION

CLEAN PROCESSES BRANCH