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US EPA - ToxCast and the Tox21 program: perspectives
Citation:
Judson, R. US EPA - ToxCast and the Tox21 program: perspectives. Presented at 48th EUROTOX 2012 Congress - Congress of the European Societies of Toxicology, Stockholm Waterfront Congress Centre, Stockholm, SWEDEN, June 17 - 20, 2012.
Impact/Purpose:
This presentation will describe the chemical library and assay battery used in ToxCast and Tox21; will outline the development of toxicity signatures; and will describe applications in areas including developmental and reproductive toxicity, cancer and endocrine signaling.
Description:
ToxCast is a large-scale project being conducted by the U.S. EPA to screen ~2000 chemicals against a large battery of in vitro high-throughput screening (HTS) assays. ToxCast is complemented by the Tox21 project being jointly carried out by the U.S. NIH Chemical Genomics Center (NCGC), the U.S. National Toxicology Program (NTP) and the EPA. Tox21 is screening a library of over 8,000 unique chemicals, including those in the ToxCast library against a smaller set of HTS assays. These programs have several scientific goals, among which are: (1) To build predictive models (toxicity signatures) of chemical toxicity linking in vitro activity to in vivo adversity; (2) to use these signatures to prioritize data-poor chemicals for more in-depth testing; and (3) to support systems biology models that can provide better understanding of the mechanistic basis of chemical toxicity. This presentation will describe the chemical library and assay battery used in ToxCast and Tox21; will outline the development of toxicity signatures; and will describe applications in areas including developmental and reproductive toxicity, cancer and endocrine signaling. [This abstract does not necessarily reflect Agency policy].