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The Neurotoxic Potential of Engineered Nanomaterials
BOYES, W. K., R. Chen, C. Chen, M. Dan, M. T. Tseng, AND R. A. Yorkel. The Neurotoxic Potential of Engineered Nanomaterials. NEUROTOXICOLOGY. Intox Press, Inc, Little Rock, AR, 33(4):902-10, (2012).
The expanding development and production of engineered nanomaterials (ENMs) have diverse and far-reaching potential benefits in consumer products, food, drugs, medical devices and for enhancing environmental cleanup and remediation. The knowledge of potential implications of ENMs, including the potential for inadvertent exposures and adverse neurotoxic consequences, is lagging behind their development. A potential risk for neurotoxicity arises if exposure leads to systemic absorption and distribution to the nervous system. This paper is the summary of a symposium entitled Neurotoxicity Potential ofEngineered Nanomaterials presented at the 2011 Xi'an International Neurotoxicology conference held June 5-9 in Xi'an China. The following topics were featured in the symposium: the toxicokinetics of engineered nanomaterials; differential uptake of nanoceria in brain and peripheral organs; association of nanoceria with the blood brain barrier; translocation into the brain and potential damage following nanoparticle exposure; and the retinal as a potential site of nanomaterial phototoxicity. Each of these topics is discussed fully in sections of the manuscript. The promising benefits of ENM technology can be best realized if the potential risks are first understood and then minimized in product and system designs. Keywords:
This paper is the summary of a symposium entitled Neurotoxicity Potential of Engineered Nanomaterials presented at the 2011 Xi'an International Neurotoxicology conference held June 5-9 in Xi'an China.
Record Details:Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB
TOXICOLOGY ASSESSMENT DIVISION