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Behavioral changes in adult and young rats as indications of cholinesterase inhibition
Citation:
MOSER, V. C. Behavioral changes in adult and young rats as indications of cholinesterase inhibition. Chapter 11, (Knaak JB, Timchalk C, Tornero-Velez R, ed) (ed.), American Chemical Society Symposium Series: Parameters for pesticide QSAR and PBPK/PD Models for Human risk assessment. American Chemical Society, Washington, DC, 1099:167-68, (2012).
Impact/Purpose:
We have evaluated behavioral changes and concurrent acetylcholinesterase inhibition in both adult and preweanling rats for a number of OPs and carbamates.
Description:
Inhibition of acetylcholinesterase has long been accepted as the basis for neurotoxicity produced by organophosphorus (OP) and N-methyl carbamate chemicals. Functional or behavioral alterations result from acute exposure to these chemicals. We have evaluated behavioral changes and concurrent acetylcholinesterase inhibition in both adult and preweanling rats for a number of OPs and carbamates. A within-subject design allows direct correlations between these variables. Overall we have shown that there are different patterns of correlation between behavior and brain acetylcholinesterase inhibition, and these differ by endpoint and chemical. Furthermore, these correlations are different between adult and young animals. Chemical-specific data may therefore be necessary to inform neurotoxicity predictions from OP and carbamate PBPKJPD models. The data presented here were presented at the 2420d National Meeting of the American Chemical Society, August 2011. The views expressed in this paper are those of the author and do not necessarily reflect the views or policies ofthe U.S. Environmental Protection Agency.