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Metal-induced Dysregulation of the NF-kB Pathway in a Detroit Michigan's Children Cohort
Citation:
Patel, R., J. GALLAGHER, J. Rigdon, AND S. W. EDWARDS. Metal-induced Dysregulation of the NF-kB Pathway in a Detroit Michigan's Children Cohort. Presented at Society of Toxicology (SOT) Annual Meeting, San Francisco, CA, March 11 - 15, 2012.
Impact/Purpose:
Heavy metal exposure can have adverse effects on childhood development, and early life exposures have been shown to modify key biological pathways. We set out to evaluate the genome-wide effects of metals exposure in the Mechanistic Indicators of Childhood Asthma (MICA) study, which investigated the relationships between environmental exposures and health effects in 205 children in Detroit, Michigan.
Description:
Heavy metal exposure can have adverse effects on childhood development, and early life exposures have been shown to modify key biological pathways. We set out to evaluate the genome-wide effects of metals exposure in the Mechanistic Indicators of Childhood Asthma (MICA) study, which investigated the relationships between environmental exposures and health effects in 205 children in Detroit, Michigan. The MICA study measured environmental metal exposure by analyzing fingernail metal concentrations. Genome-wide gene expression levels within blood samples were assessed using the Affymetrix Human Genome U133 Plus 2.0 Array. In this analysis, we examined the relationship between exposure to the four toxic metals, Arsenic (As), Cadmium (Cd), Chromium (Cr) and Mercury (Hg), and whole blood gene expression in 131 children. Using multivariate linear regression analysis and a permutation-based correction method, we identified 160, 1180, 339 and 350 uniquely modulated genes (p