You are here:
Effects of Air Pollutants on Innate Immunity: The Role of Toll-like receptors and nucleotide-binding oligomerization domain-like receptors
Citation:
Bauer, R. N., D. DIAZ SANCHEZ, AND I. JASPERS. Effects of Air Pollutants on Innate Immunity: The Role of Toll-like receptors and nucleotide-binding oligomerization domain-like receptors. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. Journal of Allergy Clinical Immunology, 129(1):14-24, (2012).
Impact/Purpose:
This review article will summarize current knowledge about how air pollutants modify TLR and NLR dependent signaling and host defense responses in the lung.
Description:
Interactions between exposure to ambient air pollutants and respiratory pathogens have been shown to modify respiratory immune responses. Emerging data suggest key roles for toll-like receptor (TLR) and NOD-like receptor (NLR) signaling in pathogen-induced immune responses. Similarly, immune responses elicited by exposure to air pollutants are mediated by specific TLR and NLR-dependent mechanisms. This review article will summarize current knowledge about how air pollutants modify TLR and NLR dependent signaling and host defense responses in the lung.
