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Defining Dose across Different Experimental Designs: Fiber Equivalent Diameter and Surface Area
Citation:
JARABEK, A. M., P. M. COOK, O. T. PRICE, S. H. GAVETT, AND B. ASGHARIAN. Defining Dose across Different Experimental Designs: Fiber Equivalent Diameter and Surface Area. Presented at Society of Environmental Toxicology and Chemistry, Boston, MA, November 13 - 17, 2011.
Impact/Purpose:
Inhaled fibers (elongated bio-durable particles) of all lengths have been shown to induce pathological responses, but different sizes are respirable in different species. To be able to accurately assess the health effects observed in toxicological or epidemiological studies, comparative potency must be assessed as a function of both the respirable and retained fractions of inhaled fibers for in-vivo and in-vitro studies, and comparative doses translated to human equivalent air exposures. In this paper we explore new techniques to translate and compare the respirable and retained fractions for different experimental designs across species. We also define and discuss relevant dose metrics based on mode of action considerations.
Description:
Inhaled fibers (elongated bio-durable particles) of all lengths have been shown to induce pathological responses, but different sizes are respirable in different species. To be able to accurately assess the health effects observed in toxicological or epidemiological studies, comparative potency must be assessed as a function of both the respirable and retained fractions of inhaled fibers for in-vivo and in-vitro studies, and comparative doses translated to human equivalent air exposures. In this paper we explore new techniques to translate and compare the respirable and retained fractions for different experimental designs across species. We also define and discuss relevant dose metrics based on mode of action considerations.