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Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors
Citation:
HUANG, R., M. XIA, M. CHO, S. SAKAMURU, P. SHINN, K. A. HOUCK, D. J. DIX, R. JUDSON, K. L. WITT, R. J. KAVLOCK, R. R. TICE, AND C. P. AUSTIN. Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 119(8):1142-1148, (2011).
Impact/Purpose:
The large and increasing number of chemicals released into the environment demand more efficient and cost effective approaches for assessing environmental chemical toxicity. The U.S. Tox21 program has responded to this challenge by proposing alternative strategies for toxicity testing, among which the quantitative high-throughput screening (qHTS) paradigm has been adopted as the primary tool for data generation on large chemical libraries against a wide spectrum of assays.
Description:
The large and increasing number of chemicals released into the environment demand more efficient and cost effective approaches for assessing environmental chemical toxicity. The U.S. Tox21 program has responded to this challenge by proposing alternative strategies for toxicity testing, among which the quantitative high-throughput screening (qHTS) paradigm has been adopted as the primary tool for data generation on large chemical libraries against a wide spectrum of assays.
URLs/Downloads:
Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors