Science Inventory

Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors

Citation:

HUANG, R., M. XIA, M. CHO, S. SAKAMURU, P. SHINN, K. A. HOUCK, D. J. DIX, R. JUDSON, K. L. WITT, R. J. KAVLOCK, R. R. TICE, AND C. P. AUSTIN. Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 119(8):1142-1148, (2011).

Impact/Purpose:

The large and increasing number of chemicals released into the environment demand more efficient and cost effective approaches for assessing environmental chemical toxicity. The U.S. Tox21 program has responded to this challenge by proposing alternative strategies for toxicity testing, among which the quantitative high-throughput screening (qHTS) paradigm has been adopted as the primary tool for data generation on large chemical libraries against a wide spectrum of assays.

Description:

The large and increasing number of chemicals released into the environment demand more efficient and cost effective approaches for assessing environmental chemical toxicity. The U.S. Tox21 program has responded to this challenge by proposing alternative strategies for toxicity testing, among which the quantitative high-throughput screening (qHTS) paradigm has been adopted as the primary tool for data generation on large chemical libraries against a wide spectrum of assays.

URLs/Downloads:

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Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Product Published Date: 08/01/2011
Record Last Revised: 08/10/2011
OMB Category: Other
Record ID: 235692

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR COMPUTATIONAL TOXICOLOGY

IMMEDIATE OFFICE