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A PROPOSED FRAMEWORK FOR ASSESSING RISK FROM LESS-THAN-LIFETIME EXPOSURES TO CARCINOGENS
Citation:
CONOLLY, R., M. Bercu, M. Bercu, A. R. Boobis, P. M. Bos, P. Carthew, N. G. Doerrer, J. I. Goodman, W. A. Harrouk, D. J. Kirkland, J. R. Preston, R. Schoeny, R. A. Schnatter, A. Tritscher, F. van Velsen, AND G. M. Williams. A PROPOSED FRAMEWORK FOR ASSESSING RISK FROM LESS-THAN-LIFETIME EXPOSURES TO CARCINOGENS. CRITICAL REVIEWS IN TOXICOLOGY. CRC Press LLC, Boca Raton, FL, 41(6):507-44, (2011).
Impact/Purpose:
To move cancer risk assessment beyond reliance on lifetime cumulative dose for less-than-lifetime exposures, a committee of the ILSI Health and Environmental Sciences Institute conducted a multi-sector workshop in late 2009 to discuss a proposed framework.
Description:
Quantitative cancer risk assessment methods have been developed for daily, lifetime human exposures, but not for exposures that are less than lifetime. Few examples for less-than-Iifetime exposures exist in the published literature. To move cancer risk assessment beyond reliance on lifetime cumulative dose for less-than-lifetime exposures, a committee of the ILSI Health and Environmental Sciences Institute conducted a multi-sector workshop in late 2009 to discuss a proposed framework. The proposed framework provides a decision tree and guidance for cancer risk assessments for less-than-lifetime exposures, using available toxicity and exposure data. This paper presents an overview of the foundation for the workshop, describes the proposed 'framework for assessing less-than-lifetime exposures to potential human carcinogens, suggests next steps, and reviews historical background.
