You are here:
Virtual Liver: integrating in vitro and in vivo data to predict chemical-induced toxicity
Citation:
SHAH, I. A. Virtual Liver: integrating in vitro and in vivo data to predict chemical-induced toxicity. Presented at Hepatotoxicity Conference, World Pharma Congress, Philadelphia, PA, June 06 - 09, 2011.
Impact/Purpose:
This is to explain how the EPA Virtual Liver aims to bridge in vitro data from the EPA ToxCast™ Project to in vivo effects through a novel cellular systems model of hepatic tissues.
Description:
It is difficult to assess the health impact of long-term exposure to low levels of contaminants from animal studies. Current methods for testing the toxicity of a single chemical can cost millions of dollars, take up to two years and sacrifice thousands of animals. In vitro models offer a more efficient and humane alternative, however, translating chemical-induced molecular changes in cell cultures to clinical outcomes remains an open problem. This talk will explain how the EPA Virtual Liver aims to bridge in vitro data from the EPA ToxCast™ Project to in vivo effects through a novel cellular systems model of hepatic tissues. [This abstract does not necessarily reflect US EPA policy].