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A Computational Model of the Hypothalamic Pituitary Gonadal Axis in Female Fathead Minnows (Pimephales promelas) exposed to 17á-ethynylestradiol and 17â-trenbolone
Citation:
LI, Z., K. J. KROLL, K. M. JENSEN, DAN VILLENEUVE, G. T. ANKLEY, J. V. BRIAN, M. SEPULVEDA, E. F. ORLANDO, J. M. LAZORCHAK, M. KOSTICH, B. ARMSTRONG, N. D. DENSLOW, AND K. H. WATANABE. A Computational Model of the Hypothalamic Pituitary Gonadal Axis in Female Fathead Minnows (Pimephales promelas) exposed to 17á-ethynylestradiol and 17â-trenbolone. BMC Systems Biology. BioMed Central Ltd, London, Uk, 5(63):1-22, (2011).
Impact/Purpose:
Endocrine disrupting chemicals (e.g., estrogens, androgens and their mimics) are known to affect reproduction in fish. 17a-ethynylestradiol is a synthetic estrogen used in birth control pills. 17a-trenbolone is a relatively stable metabolite of trenbolone acetate, a synthetic androgen used as a growth promoter in livestock. Both 17a- ethynylestradiol and 17a-trenbolone have been found in the aquatic environment and ffect fish reproduction. In this study, we developed a physiologically-based computational model in female fathead minnows (FHM, Pimephales promelas), a small fish species used in ecotoxicology, to simulate how estrogens or androgens affect reproductive endpoints, such as plasma concentrations of steroid hormones and vitellogenin (a precursor to egg yolk proteins).
Description:
Endocrine disrupting chemicals (e.g., estrogens, androgens and their mimics) are known to affect reproduction in fish. 17a-ethynylestradiol is a synthetic estrogen used in birth control pills. 17a-trenbolone is a relatively stable metabolite of trenbolone acetate, a synthetic androgen used as a growth promoter in livestock. Both 17a- ethynylestradiol and 17a-trenbolone have been found in the aquatic environment and affect fish reproduction. In this study, we developed a physiologically-based computational model in female fathead minnows (FHM, Pimephales promelas), a small fish species used in ecotoxicology, to simulate how estrogens (i.e., 17a- ethynylestradiol) or androgens (i.e., 17a-trenbolone) affect reproductive endpoints, such as plasma concentrations of steroid hormones (e.g., 17a-estradiol and testosterone) and vitellogenin (a precursor to egg yolk proteins).
