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Case Studies to Evaluate the Use of DNA Adduct Date in Cancer Risk Assessment:: Context is Key

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http://cfpub.epa.gov/si/si_public_comments.cfm

Citation:

Pottenger, L. H., L. Andrews, A. Bachman, P. Boogaard, J. Cadet, P. Farmer, M. Himmelstein, A. M. JARABEK, J. Kim, E. Martin, R. Mauthe, R. Persaud, J. PRESTON, R. S. SCHOENY, J. Skare, J. Swenberg, G. Williams, F. Zhang, AND E. Zeiger. Case Studies to Evaluate the Use of DNA Adduct Date in Cancer Risk Assessment:: Context is Key. Presented at Society of Toxicology, Washington, DC, March 06 - 10, 2011.

Impact/Purpose:

DNA adduct data alone are informative, but not sufficient to assign a mutagenic MOA.

Description:

Key conclusions include: DNA adduct data cannont be used in isolation to determine a mutagenic MOA, and DNA adducts represent biomarkers of exposure and not of effect.

URLs/Downloads:

PRESTON SOT.PDF  (PDF, NA pp,  90  KB,  about PDF)

Record Details:

Record Type:DOCUMENT( PRESENTATION/ ABSTRACT)
Product Published Date:03/10/2011
Record Last Revised:12/05/2012
OMB Category:Other
Record ID: 230526