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Virtual Tissues and Developmental Systems Biology (book chapter)
Citation:
KNUDSEN, T. B. AND G. P. DASTON. Virtual Tissues and Developmental Systems Biology (book chapter). Second Edition, Chapter 23, Knudsen,T. and Daston,G. (ed.), Comprehensive Toxicology. Elsevier Ltd, Oxford, Uk, 12:347-358, (2010).
Impact/Purpose:
A domain-applicable simulation engine would place high priority on computer models and network biology at the most basic levels of cellular decision making. The long term vision is to enable what-if questions that can be answered in silico prior to the investment into additional experimentation.
Description:
Virtual tissue (VT) models provide an in silico environment to simulate cross-scale properties in specific tissues or organs based on knowledge of the underlying biological networks. These integrative models capture the fundamental interactions in a biological system and enable key properties to emerge at a higher order of biological organization.
