You are here:
Arsenic Metabolism by Human Gut Microbiota upon in Vitro Digestion of Contaminated Soils
Citation:
Van de Wiele, T., C. GALLAWA, K. KUBACHKA, JOHN T. CREED, N. Basta, E. A. Dayton, S. Whitacre, G. D. Laing, AND K. D. BRADHAM. Arsenic Metabolism by Human Gut Microbiota upon in Vitro Digestion of Contaminated Soils. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 118(7):1004-1009, (2010).
Impact/Purpose:
We evaluated the metabolic potency of in vitro cultured human colon microbiota toward inorganic As (iAs) and As-contaminated soils.
Description:
Speciation analysis is essential when evaluating risks from, arsenic (As) exposure. In an oral exposure scenario, the importance of presystemic metabolism by gut microorganisms has been evidenced with in vivo animal models and in vitro experiments with animal microbiota. However, it is unclear whether human microbiota display similar As metabolism, especially when present in a contaminated matrix.