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Assessing EDCs in the Field: Challenges and New Approaches
Citation:
ANKLEY, G. T. Assessing EDCs in the Field: Challenges and New Approaches. Presented at Assessing Ecological Risk of Endocrine Disrupting Chemicals: State-of-the-Science Approaches Webinar, Duluth, MN, April 22, 2010.
Impact/Purpose:
This talk provide an overview of EDCs and problems they present in terms of ecological risk assessment, and present examples of the types assessment tools needed and their potential applications.
Description:
Assessing the occurrence and effects of EDCs in the environment can be challenging from a number of perspectives. For example, conventional analytical approaches and/or toxicity tests may not be appropriate to detecting very potent chemicals that impact specific pathways, and often are present as components of complex mixtures. Meeting these challenges requires short-term in vitro and in vivo assays suitable for complex mixtures, analytical/fractionation approaches to identify specific chemicals causing biological effects, diagnostic endpoints (biomarkers) indicative of endocrine mechanism of action, and approaches to link diagnostic responses to alterations in individuals and populations. This talk provide an overview of EDCs and problems they present in terms of ecological risk assessment, and present examples of the types assessment tools needed and their potential applications.