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Does Exposure Imitate Art: Exposure Science for 21st Century Toxicity Testing
Citation:
COHEN-HUBAL, E. A. Does Exposure Imitate Art: Exposure Science for 21st Century Toxicity Testing. Presented at Society of Toxicology Annual Meeting, Salt Lake City, UT, March 07 - 11, 2010.
Impact/Purpose:
Continue dialog begun at the highly successful 2008 NRC session in which the Annual Meeting participants were provided an overview of the three National Academy reports addressing key issues impacting the Society and the profession of toxicology.
Description:
This Issues Session will continue the dialog begun at the highly successful 2008 NRC session in which the Annual Meeting participants were provided an overview of the three National Academy reports addressing key issues impacting the Society and the profession of toxicology. These reports included Toxicity Testing in the 21st Century: A Vision and Strategy, Application of Toxicogenomics Technologies to Predictive Toxicology and Risk Assessment, and Models in Environmental Regulatory Decision Making. For the past two years, Toxicological Sciences has published a Forum Series on the Vision for Toxicology Testing in the 21st Century. This is the third year we have had an Issues Session at the Annual Meeting dedicated to this discussion. In this installment, the Dr. Boekelheide will provide his perspective on distinguishing adaptive from adverse responses in in vitro systems, Dr. Hubal will introduce the concept of the exposome, and Dr. Wogan will describe the scientific challenges to the exposome approach. Dr. Chris Wild has argued that we need to complement the efforts around the genome with an exposome, which he defined as representing all environmental exposures from conception onwards including exposures from diet, lifestyle, and endogenous sources as a critical interest to disease eitiology as well as influencing toxicological outcome. • Distinguishing Adaptive from Adverse Responses in the New Testing Paradigm, Kim Boekelheide, Brown University, Providence, RI • Does Expusure Imitate Art: Exposure Science for 21 st Century Toxicity Testing, Elaine Cohen Hubal, U.S. EPA, Research Triangle Park, NC • Scientific Challenges to the Exposure Approach, Gerald N. Wogan, Massachusetts Institute of Technology (MIT), Cambridge, MA