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Aeromonas caviae strain induces Th1 cytokine response in mouse intestinal tract
HAYES, S. L., D. J. LYE, C. A. McKinstry, AND S. J. VESPER. Aeromonas caviae strain induces Th1 cytokine response in mouse intestinal tract. CANADIAN JOURNAL OF MICROBIOLOGY. NRC Research Press, Ottawa, Canada, 56(1):27-31, (2010).
Develop rapid methods, e.g.QPCR, microarray analysis, etc to measure the occurrence of and quantify potential risk of exposure to waterborne pathogens, especially those on the CCL and PCCL.
Aeromonas caviae has been associated with human gastrointestinal disease. Strains of this species typically lack virulence factors (VFs) such as enterotoxins and hemolysins that are produced by other human pathogens of the Aeromonas genus,. Microarray profiling of murine small intestinal extracts, 34 h after oral infection with an A. caviae strain, provides evidence of a Th1 type immune response. A large number of gamma-interferon (γ-IFN) induced genes are up-regulated as well as several tumor necrosis factor-alpha (TNF-α) transcripts. Aeromonas caviae has always been considred an opportunistic pathogen because it lacks obvious virulence factors. This current effort suggests that an A. caviae strain can colonize the murine intestinal tract and cause what has been described by others as a dysregulatory cytokine response. This response could explain why a number of diarrheal waterborne disease cases have been attributed to A. caviae even though it lacks obvious enteropathogenic properties
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Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL EXPOSURE RESEARCH LABORATORY
MICROBIOLOGICAL AND CHEMICAL EXPOSURE ASSESSMENT DIVISION
MICROBIAL EXPOSURE RESEARCH BRANCH