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High-throughput Proteomic Screening of Chemicals for Estrogenic and Androgenic Activity Using Mass Spectrometry .
Citation:
SALINAS, K., M. J. HEMMER, P. S. HARRIS, AND S. S. VICKERY. High-throughput Proteomic Screening of Chemicals for Estrogenic and Androgenic Activity Using Mass Spectrometry . Presented at 58th ASMS Conference on Mass Spectrometry and Allied Topics, SALT LAKE CITY, UT, May 23 - 27, 2010.
Impact/Purpose:
Mass spectrometry can be used to examine protein expression profiling as a means to screen chemicals based on previously identified modes of action. High-throughput time of flight mass spectrometry, coupled with a short-term fish assay, was used to investigate changes in plasma protein expression as a means to screen chemicals for estrogenic and androgenic endocrine activity.
Description:
Abstract for presentation at the American Society for Mass Spectrometry 2010 meeting.