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Developing Methods Using ToxCast Data for the Classification and Prioritization of Antimicrobials and Inerts
Citation:
MARTIN, M. T., T. MCMAHON, T. LEIGHTON, P. SHAH, D. REIF, K. A. HOUCK, R. JUDSON, R. J. KAVLOCK, AND D. J. DIX. Developing Methods Using ToxCast Data for the Classification and Prioritization of Antimicrobials and Inerts. Presented at Society of Toxicology Annual Meeting, Salt Lake City, UT, March 07 - 11, 2010.
Impact/Purpose:
ToxCast project
Description:
Improved chemical risk management and increased efficiency of chemical prioritization, classification and assessment are major goals within EPA. Towards achieving these goals, EPA's ToxCast™ research program has been designed to rapidly screen hundreds to thousands of chemicals' potential toxicity. In ToxCast, both antimicrobials and inert ingredients are being tested in high-throughput screening systems, 22 in Phase I. Antimicrobial pesticides are chemicals designed to kill or suppress the growth of harmful microorganisms in a variety of use settings, including inanimate objects and surfaces. In total, there are over 300 antimicrobial pesticide active ingredients. Roughly 100 antimicrobial pesticides have undergone re-registration via 41 REDs (re-registration eligibility decision documents), leaving over 200 antimicrobial pesticides requiring some form of hazard evaluation that could be provided by ToxCast. Inert ingredients are substances that are not active ingredients, but which are intentionally included in pesticide products. Limited toxicity data exists for thousands of inert (other) ingredients, creating a need to efficiently determine the potential toxicity of these chemicals. Through the use of ToxCast, toxicity potential has been modeled based on biological activity, pathway-based effects, and estimated dosimetry with a special focus on systemic, cancer, reproductive, and developmental effects. These predictive toxicity scores can then be considered and integrated into the decision process, based on the specific needs of the chemical programs, for classifying antimicrobials and inerts and prioritzing further toxicity testing. This work does not necessarily reflect official Agency policy.
URLs/Downloads:
Developing Methods Using ToxCast Data for the Classification and Prioritization of Antimicrobials and Inerts (abs) (PDF, NA pp, 8 KB, about PDF)Developing Methods Using ToxCast Data for the Classification and Prioritization of Antimicrobials and Inerts (poster) (PDF, NA pp, 271 KB, about PDF)