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Reverse Engineering Adverse Outcome Pathways in Ecotoxicology
Perkins, E., K. Chipman, S. W. EDWARDS, T. Habib, F. Falciani, R. Taylor, G. Van Aggelen, C. Vulpe, AND P. Antczak. Reverse Engineering Adverse Outcome Pathways in Ecotoxicology. RISK ANALYSIS. Blackwell Publishing, Malden, MA, 30(1):22-38, (2011).
The toxicological effects of many stressors are mediated through unknown, or incompletely characterized, mechanisms of action. We describe the application of reverse engineering complex interaction networks from high dimensional omics data (gene, protein, meabolic, signaling) to characterize adverse outcome pathways for chemicals that disrupt the hypothalamus-pituitary-gonadal endocrine axis in fathead minnows.
We identify the unique challenges facing the application of this approach in ecotoxicology, and attempt to provide a road map for the utilization of these tools.
Record Details:Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB
ASSOCIATE DIRECTOR FOR HEALTH