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Reverse Engineering Adverse Outcome Pathways in Ecotoxicology
Citation:
Perkins, E., K. Chipman, S. W. EDWARDS, T. Habib, F. Falciani, R. Taylor, G. Van Aggelen, C. Vulpe, AND P. Antczak. Reverse Engineering Adverse Outcome Pathways in Ecotoxicology. RISK ANALYSIS. Blackwell Publishing, Malden, MA, 30(1):22-38, (2011).
Impact/Purpose:
We identify the unique challenges facing the application of this approach in ecotoxicology, and attempt to provide a road map for the utilization of these tools.
Description:
The toxicological effects of many stressors are mediated through unknown, or incompletely characterized, mechanisms of action. We describe the application of reverse engineering complex interaction networks from high dimensional omics data (gene, protein, meabolic, signaling) to characterize adverse outcome pathways for chemicals that disrupt the hypothalamus-pituitary-gonadal endocrine axis in fathead minnows.