EPA Science Inventory

Application of Novel Method to Measure Endogenous VOCs in Exhaled Breath Condensate Before and After Exposure to Diesel Exhaust

Citation:

HUBBARD, H., J. SOBUS, J. D. PLEIL, M. C. MADDEN, AND S. Tabucchi. Application of Novel Method to Measure Endogenous VOCs in Exhaled Breath Condensate Before and After Exposure to Diesel Exhaust. JOURNAL OF CHROMATOGRAPHY: B BIOMEDICAL SCIENCES AND APPLICATIONS. Elsevier Science Ltd, New York, NY, 877(29):3652-3658, (2009).

Description:

Polar volatile organic compounds (PVOCs) such as aldehydes, ketones, and alcohols are byproducts of normal human metabolism and are present in exhaled breath and blood. Environmental exposures, individual activities, and disease states can perturb normal metabolic processes and can be expressed as a change in the patterns of the PVOCs. Under controlled or monitored conditions it may be possible to directly attribute changes to external sources. Results of these controlled exposures could then be used to assess unknown exposures in population based studies.

Purpose/Objective:

The National Exposure Research Laboratory′s (NERL) Human Exposure and Atmospheric Sciences Division (HEASD) conducts research in support of EPA′s mission to protect human health and the environment. HEASD′s research program supports Goal 1 (Clean Air) and Goal 4 (Healthy People) of EPA′s strategic plan. More specifically, our division conducts research to characterize the movement of pollutants from the source to contact with humans. Our multidisciplinary research program produces Methods, Measurements, and Models to identify relationships between and characterize processes that link source emissions, environmental concentrations, human exposures, and target-tissue dose. The impact of these tools is improved regulatory programs and policies for EPA.

URLs/Downloads:

Application of Novel Method to Measure Endogenous VOCs in Exhaled Breath Condensate before and After Exposure to Diesel Exhaust   (PDF,NA pp, 6114 KB,  about PDF)

Journal of Chromatography B   Exit

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 11/01/2009
Completion Date: 11/01/2009
Record Last Revised: 03/19/2010
Record Created: 06/17/2009
Record Released: 06/17/2009
OMB Category: Other
Record ID: 210203

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL EXPOSURE RESEARCH LAB

HUMAN EXPOSURE AND ATMOSPHERIC SCIENCES DIVISION

METHODS DEVELOPMENT & APPLICATION BRANCH