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Advances In Assessing Bioavailability Of Metal(Loid)s In Contaminated Soils
Citation:
SCHECKEL, K. G., R. L. Chaney, N. T. Basta, AND JAMES A. RYAN. Advances In Assessing Bioavailability Of Metal(Loid)s In Contaminated Soils. Chapter 1, D. L. Sparks (ed.), Advances in Agronomy. Elsevier BV, AMSTERDAM, Netherlands, 104:1-52, (2009).
Impact/Purpose:
To develop a mechanistic understanding of the bioavailability processes to improve the science of risk assessment and to develop predictive models derived from sound research.
Description:
The term bioavailability has many different meanings across various disciplines of toxicology and pharmacology. Often bioavailability is concerned with human health aspects such as in the case of lead (Pb) ingestion by children. However, some of the most contaminated sites are found in nonpublic access facilities (Departments of Defense or Energy) or in remote regions as a result of mining or industrial practices in which ecoreceptors such as plants, animals, and soil organisms are the primary concerns as well as the potential for food-chain transfer. In all cases, the endpoint requires movement of the element across a biological barrier. The still utilized approach to base risk assessment on total metal content in soils is an outdated endeavor and has never been proved to be scientifically sound. Yet to reverse this trend, much work is required to establish baseline bioavailability measurements and to develop complementary methods that are capable of predicting bioavailability across a whole range of impacted media in a cost-efficient manner. Thus, regulators have recognized that site-specific human health risk assessments play a key role in decision-making processes at contaminated sites. Bioavailability issues surrounding metal-contaminated soils and media have been an area of intense research. For obvious ethical reasons, we cannot solicit humans, in particular the sensitive population of children, from the general population for experimental purposes to examine the long-term harmful effect of metals in soils. However, some adult human feeding studies have been accomplished under tight medical supervision and with very small doses. One option to understand and relate bioavailability in humans is to employ animal surrogates; however, the physiology of most animals is different than that of humans but good correlations have been achieved despite the dose-response paradigm not being identical. The biggest drawback of in vivo studies to examine metal bioavailability to an appropriate ecoreceptor, be it human, plant, or soil organism, is the tremendous cost and time involved relative to chemical and physical surrogates. Chemical surrogate methods generally only require knowledge of the total metal content so that a percent bioaccessible number can be generated from in vitro extractions that simulate digestive systems or mimic responses to sensitive ecoreceptors. However, there is not a consensus as to which of the many in vitro methods is the best analogy to an ecoreceptor uptake and the same can be said for in vivo animal models to mimic human response as well. Further, there is yet to be a single in vitro method that can account for more than a few elements for a specific exposure pathway (e.g., Pb and/or arsenic (As) for human health). These in vitro tests require honest and accurate validation against in vivo bioavailability measurements, but most of all would benefit from metal speciation methods to identify the forms of metals allowing their release. Adaptation of spectroscopic speciation techniques to identify metal(loid) phases is extremely beneficial in bioavailablilty research to understand the variability of biologically available metal uptake, to manipulate the ecosystem to reduce bioavailability via in-situ amendments, to monitor the long-term stability of elements to ensure bioavailability indicators do not change over time, and to develop comprehensive predictive models based on speciation.
