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Potential for Metabolomics-Based Markers of Exposure:Encouraging Evidence from Studies using Model Organisms
Citation:
COLLETTE, T. W., D. R. EKMAN, AND Q. TENG. Potential for Metabolomics-Based Markers of Exposure:Encouraging Evidence from Studies using Model Organisms. Presented at 19th Annual International Society of Exposure Science Conference, Minneapolis, MN, November 01 - 05, 2009.
Impact/Purpose:
The mission of the ERD Metabolomics Team is to study the impact of stressors on various species using NMR and other advanced analytical approaches to characterize changes in endogenous metabolites. The main focus is to define responses in ecologically-relevant organisms (e.g., small fish) upon exposure to potentially toxic xenobiotic chemicals. Results will: determine markers of exposure, define how exposure events are linked to whole-organism outcomes, and provide ORD’s customers with information that aids in risk assessments.
Description:
Genomic techniques (transcriptomics, proteomics, and metabolomics) have the potential to significantly improve the way chemical risk is managed in the 21st century. Indeed, a significant amount of research has been devoted to the use of these techniques to screen chemicals for hazardous effects. However, changes in transcripts, proteins, and endogenous metabolites may, in some cases, be more-certain indicators of chemical exposures than of apical chemical effects. Nonetheless, these powerful new techniques have rarely been applied as markers of exposure. Metabolomics may be a particularly powerful genomic tool for developing markers for both human and ecological exposures. For human exposures, it is important to note that metabolomics can be conducted effectively on biofluids that can be collected non-invasively from humans (e.g., urine, breath condensate, saliva) regardless of the ultimate disposition of the anthropogenic chemical. For ecological exposures, it is important to note that metabolomics can be conducted effectively without the need for a sequenced genome, and that metabolism is often conserved across species. We will illustrate here the advantages of metabolomics for developing markers of exposure, using results from studies with, e.g., fathead minnows, rodents and cell-cultures exposed to a variety of chemical stressors.
URLs/Downloads:
COLLETTE 09 063 ISES 2009 ABSTRACT .PDF (PDF, NA pp, 11 KB, about PDF)COLLETTE 09 063A ISES POSTER.PDF (PDF, NA pp, 142 KB, about PDF)