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Changes in Markers of Genotoxicity in Relation to Exposure to Disinfection By-Products in Swimming Pools
Citation:
Kogevinas, M., C. Villanueva, L. Font, M. Nieuwinhuijsen, S. D. RICHARDSON, T. Grummt, J. Grimalt, AND R. Marcos. Changes in Markers of Genotoxicity in Relation to Exposure to Disinfection By-Products in Swimming Pools. Presented at ISEE 2009 Conference, Dublin, Northern Ireland, IRELAND, August 25 - 29, 2009.
Impact/Purpose:
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Description:
Exposure to disinfection by-products (DBPs) has been associated with cancer risk, but the mechanisms of action are poorly understood. A recent study found increased bladder cancer risk among subjects attending swimming pools, where uptake of DBPs, such as trihalomethanes (THMs) can be particularly high through dermal absorption and inhalation. We evaluated in an experimental study whether swimming in pools was associated with markers of genotoxicity. We identified increases in markers of genotoxicity associated with exposure to THMs in swimming pools. These increases were modest, and findings should be verified in larger studies.