Citation:

COHEN-HUBAL, E. A., J. Little, O. Jolliet, AND H. Clewell. Source-to-Dose Modeling of Phthalates: Lessons for Prioritization. Presented at International Society of Exposure Analysis, International Society of Environmental Epidemiology Joint Annual Conference, Pasadena, CA, October 12 - 16, 2008.

Impact/Purpose:

Ideas discussed in this symposium will help develop an approach for characterizing exposure that can be used with ToxCast predictions to prioritize thousands of uncharacterized environmental pollutants.

Description:

Globally there is a need to characterize potential risk to human health and the environment that arises from the manufacture and use of tens of thousands of chemicals. The US EPA is developing methods for using computational chemistry, high-throughput screening, and toxicogenomic technologies to predict potential toxicity and prioritize limited testing resources. This chemical prioritization research program, called ToxCast, will develop the ability to forecast toxicity based on bioactivity profiling. Currently in the pilot phase of ToxCast, the need to include exposure assessment has been identified. In this symposium, we will present state-of-the-art tools for modeling exposure of phthalates and other semi-volatile organic compounds (SVOCs) from emitting source to metabolic sink or dose. Speakers will show how data analysis and modeling can be used to identify determinants of exposure that apply to a broad range of compounds (for example, an understanding of the mechanisms governing release of and exposure to phthalates can be applied to understand the behavior of other SVOCs such as pesticides, flame retardants, and biocides).

Record Details: