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Thyroid Disrupting Chemicals: Interpreting Upstream Biomarkers of Adverse Outcomes
Citation:
MILLER, M. D., K. M. CROFTON, D. C. RICE, AND T. ZOELLER. Thyroid Disrupting Chemicals: Interpreting Upstream Biomarkers of Adverse Outcomes. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 117(7):1033-1041, (2009).
Impact/Purpose:
We review the role of TH in nervous system development and specific outcomes in adults, the impact of xenobiotics on thyroid signaling, the relationship between adverse outcomes of thyroid disruption and upstream causal biomarkers, and the societal implications of perturbations in thyroid signaling by xenobiotic chemicals.
Description:
There is increasing evidence in humans and in experimental animals for a relationship between exposure to specific environmental chemicals and perturbations in levels of critically important thyroid hormones (THs). Identification and proper interpretation of these relationships are required for accurate assessment of risk to public health.
