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Revisiting Bioaccumulation Criteria for POPS and PBT Assessments
Citation:
GOBAS, F., W. DE WOLF, L. P. BURKHARD, E. VERBRUGGEN, AND K. PLOTZKE. Revisiting Bioaccumulation Criteria for POPS and PBT Assessments. Allen Press, Inc., Lawrence, KS, 2009.
Impact/Purpose:
The proposed framework for bioaccumulation screening improves current practices by reducing miscategorization, making more effective use of available bioaccumulation data that currently cannot be considered, reducing the need for animal testing, providing simpler and cheaper test protocols for animal studies in case animal studies are necessary, making use of alternative testing strategies including in- vitro and in silico metabolic transformation assays and by providing a scientific foundation for bioaccumulation screening that can act to harmonize bioaccumulation screening among various jurisdictions.
Description:
Scientists from academia, industry and government reviewed current international regulations for the screening of commercial chemicals for bioaccumulation in the context of the current state of the science in the area of bioaccumulation. Based on this review several recommendations were proposed. Recommendations include a scientific definition for “bioaccumulative substances”, improved criteria for the characterization of bioaccumulative substances (including the trophic magnification factor and the bio magnification factor), novel methods for measuring and calculating bioaccumulation properties and a framework for screening commercial chemicals for bioaccumulative substances. The proposed framework for bioaccumulation screening improves current practices by reducing miscategorization, making more effective use of available bioaccumulation data that currently cannot be considered, reducing the need for animal testing, providing simpler and cheaper test protocols for animal studies in case animal studies are necessary, making use of alternative testing strategies including in- vitro and in silico metabolic transformation assays and by providing a scientific foundation for bioaccumulation screening that can act to harmonize bioaccumulation screening among various jurisdictions.