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Microwave-Assisted Organic Synthesis Using Benign Reaction Medium and Reagents
Citation:
VARMA, R. S. AND V. Polshettiwar. Microwave-Assisted Organic Synthesis Using Benign Reaction Medium and Reagents. Presented at Global Congress on Microwave Energy Appliations (GCMEA) 2008`, Otsu, JAPAN, August 04 - 08, 2008.
Impact/Purpose:
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Description:
Account of chemical reactions expedited by microwave (MW) exposure of neat reactants for the rapid one-pot assembly of heterocyclic compounds from in situ generated reactive intermediates via enamines or using hypervalent iodine reagents will be described that can be adapted for parallel synthesis in multicomponent reactions. The eco-friendly nucleophilic substitution chemistry in water can be manipulated using microwaves to generate cyclic amines via double N-alkylation of primary amines or hydrazines by dihalides or tosylates. Greener protocols for the synthesis of pharmaceutically active heterocycles namely N-aryl azacycloalkanes, isoindoles, and dihydropyrazoles, 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, 1,3-dioxanes, pyrazoles, hydrazones and 3,4-dihydropyrimidin-2(1H)-ones, catalyzed by basic water or polystyrene sulfonic acid (PSSA) in aqueous media or solid supported Nafion® NR50, under solvent-free conditions will be described including atom-economic Ritter reaction for the synthesis of amides.
