You are here:
Comparing Single and Repeated Dosimetry Data for Perfluorooctane Suflonate in Rats
Citation:
HARRIS, L. A. AND H. A. BARTON. Comparing Single and Repeated Dosimetry Data for Perfluorooctane Suflonate in Rats. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART B: CRITICAL REVIEWS. Taylor & Francis, Inc., Philadelphia, PA, 181(3):148-156, (2008).
Impact/Purpose:
A mathematical model that describes the disposition of PFOS in adult rats following intravenous, oral, and chronic dietary exposures was developed to gain a better understanding of the pharmacokinetics of PFOS and to determine whether single-dose kinetics are predictive of repeated-dose kinetics. In order to characterize existing time-course data, time-dependent and concentration-dependent changes in the pharmacokinetic parameters for urinary and biliary clearance and liver distribution were needed. Whether these time dependent changes represent inconsistencies across experiments, effects of aging in the rats, or chemically induced changes in pharmacokinetics remains to be determined.
Description:
Perfluorooctane sulfonate (PFOS) is a member of a class of perfluorinated chemicals used in a variety of consumer and industrial applications because of their oleophobic and hydrophobic properties. It has been shown to cause toxicity in adult and developing laboratory animals. Because PFOS has also been shown to be widely distributed throughout the environment, there have been concerns about its potential health risk to humans. Little is known about the effects of PFOS in humans; however, existing pharmacokinetic and toxicity studies in laboratory animals can be useful in cross-species extrapolations needed to evaluate internal dosimetry in humans.
