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Exhaled breath malondialdehyde as a matter of effect of exposure to airpollution in children with asthma
Romieu, I., A. Barraza-Villarreal, C. Escamilla-Nunez, A. C. Almstrand, D. DIAZ SANCHEZ, P. D. Sly, AND A. C. Olin. Exhaled breath malondialdehyde as a matter of effect of exposure to airpollution in children with asthma. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. Journal of Allergy Clinical Immunology, 121(4):903-909, (2008).
BACKGROUND: Assessment of the adverse effects of oxidative stress related to air pollution is limited by the lack of biological markers of dose to the lungs. OBJECTIVE: We evaluated the use of exhaled breath condensate (EBC) malondialdehyde as a biomarker of exposure to traffic-related pollution in children with asthma as part of a panel study in Mexico City. METHODS: Standard spirometry and collection of EBC and nasal lavage were performed. Environmental monitoring sites were located within 5 km of the children's homes and schools. Data were analyzed by using generalized estimating equations. RESULTS: A total of 480 samples of malondialdehyde were obtained from 107 patients with asthma, with a median level of 18.7 (interquartile range [IQR], 12.4-28.7) nmol. Ambient particulates less than 2.5 microg/m(3) and ozone levels on the day of sampling were significantly associated with higher malondialdehyde levels. A 14.2-microg/m(3) (IQR) increase in 8-hour moving average particulates less than 2.5 microg/m(3) in size was associated with a 1.12-nmol increase in malondialdehyde and a 15.9-ppb (IQR) increase in 8-hour moving average ozone with a 1.16-nmol increase in malondialdehyde. Malondialdehyde levels were inversely associated with forced vital capacity and FEV(1) and positively associated with IL-8 levels in nasal lavage. CONCLUSION: Exhaled breath condensate malondialdehyde was related to both air pollution exposure and changes in lung function and inflammatory markers. PMID: 18234317 [PubMed - in process] Related ArticlesEffects of urban air pollutants on emergency visits for childhood asthma in Mexico City. [Am J Epidemiol. 1995] Lung function growth in children with long-term exposure to air pollutants in Mexico City. [Am J Respir Crit Care Med. 2007] The effect of ambient air pollution on respiratory health of school children: a panel study. [Environ Health. 2008] Traffic-related exposures, airway function, inflammation, and respiratory symptoms in children. [Am J Respir Crit Care Med. 2007] Association of low-level ozone and fine particles with respiratory symptoms in children with asthma. [JAMA. 2003] » See all Related Articles...
Record Details:Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB
HUMAN STUDIES DIVISION
CLINICAL RESEARCH BRANCH